Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women

Settembre 28th, 2020|

Abstract Importance  Endometrial carcinoma (EC) is the most commonly diagnosed gynecologic cancer. Its early detection is advisable because 20% of women have advanced disease at the time of diagnosis. Objective  To clinically validate a metabolomics-based classification algorithm as a screening test for [...]

Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis

Luglio 19th, 2020|

Abstract Worldwide, up to 20% of children and adolescents experience mental disorders, which are the leading cause of disability in young people. Research shows that serum zonulin levels are associated with increased intestinal permeability (IP), affecting neural, hormonal, and immunological [...]

  • Citrus sinensis and Vitis vinifera Protect Cardiomyocytes

Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies

Maggio 2nd, 2020|

Abstract The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean [...]

  • Clues to Autism’s Origins

Clues to Autism’s Origins

Febbraio 25th, 2020|

Abnormally low levels of a key protein observed in brains of young men with autism spectrum disorder. A neuroimaging study by Harvard Medical School researchers based at Massachusetts General Hospital has shown that the brains of young men with autism [...]

Iron Overload Mimicking Conditions Skews Bone Marrow Dendritic Cells Differentiation into MHCIIlowCD11c+CD11b+F4/80+ Cells

Febbraio 17th, 2020|

Abstract Iron overload is an undesired effect of frequent blood transfusions or genetic diseases. Myelodysplastic syndrome (MDS) patients become transfusion dependent, but due to the combination of ineffective haematopoiesis and repeated blood transfusions they are often subject to iron overload. [...]

  • All disease begins in the (leaky) gut

All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases

Febbraio 6th, 2020|

Abstract Improved hygiene leading to reduced exposure to microorganisms has been implicated as one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in industrialized countries. That is the essence of the hygiene hypothesis that argues that rising [...]

  • Indole-3-lactic acid a metabolite of tryptophan

Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine

Gennaio 16th, 2020|

Abstract Background Necrotizing enterocolitis (NEC), a necrotic inflammation of the intestine, represents a major health problem in the very premature infant. Although prevention is difficult, the combination of ingestion of maternal-expressed breastmilk in conjunction with a probiotic provides the best [...]

  • children’s cancer drug

Shortage of vital children’s cancer drug stirs fear and outrage

Ottobre 18th, 2019|

A critical shortage of a chemotherapy used to treat most childhood cancers has galvanized oncologists and parents of sick children. The U.S. medical community has become increasingly accustomed to dealing with chronic shortages of mainstay drugs, but vincristine is irreplaceable—and a big [...]

  • Radiaton Drug combos

Some Radiaton-Drug combos just make side effects worse

Ottobre 2nd, 2019|

Taking certain cancer-fighting drugs while undergoing radiation therapy may not increase survival, but could instead increase side effects, according new study. The drugs may still benefit patients who aren’t undergoing radiation therapy, say the researchers. In a meta-analysis, researchers find [...]

  • Up and down the ladder

Up and down the ladder: The latest comings and goings

Agosto 23rd, 2019|

Hired someone new and exciting? Promoting a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others. That’s right. Send us your changes, and we’ll find a home for them. Don’t be shy. [...]

  • personalize radiation treatment

Researchers develop model to personalize radiation treatment

Agosto 22nd, 2019|

A personalized approach to cancer treatment has become more common over the last several decades, with numerous targeted drugs approved to treat particular tumor types with specific mutations or patterns. However, this same personalized strategy has not translated to radiation [...]