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10 01, 2023

In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents

2023-01-10T15:46:55+01:00Gennaio 10th, 2023|Pubblicazioni|0 Commenti

Abstract Different molecular mechanisms contribute to the development of multidrug resistance in cancer, including increased drug efflux, enhanced cellular repair mechanisms and alterations of drug [...]

23 12, 2022

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

2023-01-20T20:39:39+01:00Dicembre 23rd, 2022|Pubblicazioni|0 Commenti

Abstract Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor [...]

21 12, 2022

Editorial: Novel Strategies in Drug Development Against Multifactorial Diseases

2022-12-21T21:20:11+01:00Dicembre 21st, 2022|Pubblicazioni|0 Commenti

Editorial on the Research Topic Novel Strategies in Drug Development Against Multifactorial Diseases The complexity of multifactorial diseases, such as inflammation, cancer, neurodegenerative disorders, infectious [...]

21 12, 2022

Corrigendum: Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides

2022-12-21T21:16:07+01:00Dicembre 21st, 2022|Pubblicazioni|0 Commenti

A Corrigendum on Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides by Scala, M. C., Di Micco, S., Lanzillotta, D., Musella, S., Di [...]

26 11, 2022

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization

2022-11-26T10:56:11+01:00Novembre 26th, 2022|Pubblicazioni|0 Commenti

Abstract The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we [...]

16 11, 2022

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES-1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

2022-11-16T14:18:42+01:00Novembre 16th, 2022|Pubblicazioni|0 Commenti

Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase-1 (mPGES-1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different [...]

16 11, 2022

Identification of 2,4-Dinitro-Biphenyl-Based Compounds as MAPEG Inhibitors

2022-11-16T14:09:58+01:00Novembre 16th, 2022|Pubblicazioni|0 Commenti

Abstract Multipronged strategy: 2,4-Dinitro-biphenyl-based compounds were identified as inhibitors of leukotriene C4 synthase (LTC4S) and 5-lipoxygenase-activating protein (FLAP), both members of the “Membrane Associated Proteins in [...]

16 11, 2022

Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2

2022-11-16T14:06:27+01:00Novembre 16th, 2022|Pubblicazioni|0 Commenti

Abstract Although vaccines are greatly mitigating the worldwide pandemic diffusion of SARS-Cov-2, therapeutics should provide many distinct advantages as complementary approach to control the viral [...]

9 09, 2022

Indocyanine Green Endoscopy for Pituitary Adenomas with Parasellar Extension: Results from a Preliminary Case Series

2022-09-09T12:25:11+02:00Settembre 9th, 2022|Pubblicazioni|0 Commenti

Abstract Background Advances in visualization tools have brought new confidence, including endoscope-integrated indocyanine (E-ICG), which makes pituitary and skull-base surgery safer and more effective. We report here [...]

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