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20 05, 2022

“Sagittal Crest”: Definition, Stepwise Dissection, and Clinical Implications From a Transorbital Perspective

2022-05-20T10:23:23+02:00Maggio 20th, 2022|Pubblicazioni|0 Commenti

Abstract BACKGROUND:  The recent development of the superior eyelid endoscopic transorbital approach (SETOA) offered a new route for the management of cavernous sinus and middle cranial fossa tumors. As a result, a constant anatomic landmark [...]

23 03, 2022

Zonulin Antagonist, Larazotide (AT1001), As an Adjuvant Treatment for Multisystem Inflammatory Syndrome in Children: A Case Series

2022-03-23T18:44:33+01:00Marzo 23rd, 2022|Pubblicazioni|0 Commenti

Abstract OBJECTIVES:  A recent study suggests that Multisystem Inflammatory Syndrome in Children (MIS-C) is triggered by gastrointestinal breach of severe acute respiratory syndrome coronavirus 2 [...]

24 02, 2022

Optimization of Peripheral Blood Mononuclear Cell Extraction from Small Volume of Blood Samples: Potential Implications for Children-Related Diseases

2022-03-03T20:53:40+01:00Febbraio 24th, 2022|Pubblicazioni|0 Commenti

Abstract Managing medical procedures for children with problematic disorders is a challenging approach, especially in the case of blood withdrawal for autism spectrum disorder-affected children. [...]

22 10, 2021

Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

2021-10-22T19:49:41+02:00Ottobre 22nd, 2021|Pubblicazioni|0 Commenti

Abstract COVID-19 pandemic, starting from the latest 2019, and caused by SARS-CoV-2 pathogen, led to the hardest health-socio-economic disaster in the last century. Despite the [...]

30 08, 2021

Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation

2021-10-08T16:37:02+02:00Agosto 30th, 2021|Pubblicazioni|0 Commenti

Abstract A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as the pathogen responsible for the outbreak of a severe, rapidly [...]

7 05, 2021

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition

2021-09-10T11:28:32+02:00Maggio 7th, 2021|Pubblicazioni|0 Commenti

We report the implementation of our in silico/synthesis pipeline by targeting the glutathione-dependent enzyme mPGES-1, a valuable macromolecular target in both cancer therapy and inflammation therapy. [...]

22 02, 2021

Artificial Intelligence: the “Trait D’Union” in Different Analysis Approaches of Autism Spectrum Disorder Studies

2021-04-26T12:25:21+02:00Febbraio 22nd, 2021|Pubblicazioni|0 Commenti

Abstract Autistic Spectrum Disorder (ASD) is a neurodevelopmental condition affecting approximately 1 out of 70 (range 1:59 - 1:89) children worldwide. It is characterized by [...]

20 02, 2021

Humoral signatures of protective and pathological SARS-CoV-2 infection in children

2021-02-20T18:55:53+01:00Febbraio 20th, 2021|Pubblicazioni|0 Commenti

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience [...]

12 02, 2021

Humoral signatures of protective and pathological SARS-CoV-2 infection in children

2021-04-26T12:31:19+02:00Febbraio 12th, 2021|Pubblicazioni|0 Commenti

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children [...]

15 01, 2021

In silico Analysis Revealed Potential Anti-SARS-CoV-2 Main Protease Activity by the Zonulin Inhibitor Larazotide Acetate

2021-01-15T12:52:46+01:00Gennaio 15th, 2021|Pubblicazioni|0 Commenti

Abstract The most severe outcome of COVID-19 infection is the development of interstitial pneumonia causing acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS), [...]

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