Abstract Objective To systematically assess credibility and certainty of associations between cannabis, cannabinoids, and cannabis based medicines and human health, from observational studies and randomised [...]
Abstract Schizophrenia substantially contributes to the burden of mental disorders. Schizophrenia’s burden and epidemiological estimates in some countries have been published, but updated estimates of [...]
Abstract INTRODUCTION: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS: A subgroup [...]
Abstract Different molecular mechanisms contribute to the development of multidrug resistance in cancer, including increased drug efflux, enhanced cellular repair mechanisms and alterations of drug [...]
Abstract Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor [...]
Editorial on the Research Topic Novel Strategies in Drug Development Against Multifactorial Diseases The complexity of multifactorial diseases, such as inflammation, cancer, neurodegenerative disorders, infectious [...]
A Corrigendum on Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides by Scala, M. C., Di Micco, S., Lanzillotta, D., Musella, S., Di [...]
Abstract The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we [...]
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase-1 (mPGES-1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different [...]
Abstract Multipronged strategy: 2,4-Dinitro-biphenyl-based compounds were identified as inhibitors of leukotriene C4 synthase (LTC4S) and 5-lipoxygenase-activating protein (FLAP), both members of the “Membrane Associated Proteins in [...]
