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26 11, 2022

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization

2022-11-26T10:56:11+01:00Novembre 26th, 2022|Pubblicazioni|0 Commenti

Abstract The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we [...]

16 11, 2022

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES-1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

2022-11-16T14:18:42+01:00Novembre 16th, 2022|Pubblicazioni|0 Commenti

Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase-1 (mPGES-1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different [...]

16 11, 2022

Identification of 2,4-Dinitro-Biphenyl-Based Compounds as MAPEG Inhibitors

2022-11-16T14:09:58+01:00Novembre 16th, 2022|Pubblicazioni|0 Commenti

Abstract Multipronged strategy: 2,4-Dinitro-biphenyl-based compounds were identified as inhibitors of leukotriene C4 synthase (LTC4S) and 5-lipoxygenase-activating protein (FLAP), both members of the “Membrane Associated Proteins in [...]

16 11, 2022

Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2

2022-11-16T14:06:27+01:00Novembre 16th, 2022|Pubblicazioni|0 Commenti

Abstract Although vaccines are greatly mitigating the worldwide pandemic diffusion of SARS-Cov-2, therapeutics should provide many distinct advantages as complementary approach to control the viral [...]

9 09, 2022

Indocyanine Green Endoscopy for Pituitary Adenomas with Parasellar Extension: Results from a Preliminary Case Series

2022-09-09T12:25:11+02:00Settembre 9th, 2022|Pubblicazioni|0 Commenti

Abstract Background Advances in visualization tools have brought new confidence, including endoscope-integrated indocyanine (E-ICG), which makes pituitary and skull-base surgery safer and more effective. We report here [...]

20 05, 2022

“Sagittal Crest”: Definition, Stepwise Dissection, and Clinical Implications From a Transorbital Perspective

2022-05-20T10:23:23+02:00Maggio 20th, 2022|Pubblicazioni|0 Commenti

Abstract BACKGROUND:  The recent development of the superior eyelid endoscopic transorbital approach (SETOA) offered a new route for the management of cavernous sinus and middle cranial fossa tumors. As a result, a constant anatomic landmark [...]

23 03, 2022

Zonulin Antagonist, Larazotide (AT1001), As an Adjuvant Treatment for Multisystem Inflammatory Syndrome in Children: A Case Series

2022-03-23T18:44:33+01:00Marzo 23rd, 2022|Pubblicazioni|0 Commenti

Abstract OBJECTIVES:  A recent study suggests that Multisystem Inflammatory Syndrome in Children (MIS-C) is triggered by gastrointestinal breach of severe acute respiratory syndrome coronavirus 2 [...]

24 02, 2022

Optimization of Peripheral Blood Mononuclear Cell Extraction from Small Volume of Blood Samples: Potential Implications for Children-Related Diseases

2022-03-03T20:53:40+01:00Febbraio 24th, 2022|Pubblicazioni|0 Commenti

Abstract Managing medical procedures for children with problematic disorders is a challenging approach, especially in the case of blood withdrawal for autism spectrum disorder-affected children. [...]

22 10, 2021

Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

2021-10-22T19:49:41+02:00Ottobre 22nd, 2021|Pubblicazioni|0 Commenti

Abstract COVID-19 pandemic, starting from the latest 2019, and caused by SARS-CoV-2 pathogen, led to the hardest health-socio-economic disaster in the last century. Despite the [...]

30 08, 2021

Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation

2021-10-08T16:37:02+02:00Agosto 30th, 2021|Pubblicazioni|0 Commenti

Abstract A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as the pathogen responsible for the outbreak of a severe, rapidly [...]

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