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Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies

Abstract Objective To systematically assess credibility and certainty of associations between cannabis, cannabinoids, and cannabis based medicines and human health, from observational studies and randomised [...]

2023-08-31T10:48:34+02:00Agosto 30th, 2023|Pubblicazioni|

Incidence, prevalence, and global burden of schizophrenia – data, with critical appraisal, from the Global Burden of Disease (GBD) 2019

Abstract Schizophrenia substantially contributes to the burden of mental disorders. Schizophrenia’s burden and epidemiological estimates in some countries have been published, but updated estimates of [...]

2023-08-02T11:20:37+02:00Agosto 2nd, 2023|Pubblicazioni|

In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents

Abstract Different molecular mechanisms contribute to the development of multidrug resistance in cancer, including increased drug efflux, enhanced cellular repair mechanisms and alterations of drug [...]

2023-01-10T15:46:55+01:00Gennaio 10th, 2023|Pubblicazioni|

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

Abstract Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor [...]

2023-01-20T20:39:39+01:00Dicembre 23rd, 2022|Pubblicazioni|

Editorial: Novel Strategies in Drug Development Against Multifactorial Diseases

Editorial on the Research Topic Novel Strategies in Drug Development Against Multifactorial Diseases The complexity of multifactorial diseases, such as inflammation, cancer, neurodegenerative disorders, infectious [...]

2022-12-21T21:20:11+01:00Dicembre 21st, 2022|Pubblicazioni|

Corrigendum: Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides

A Corrigendum on Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides by Scala, M. C., Di Micco, S., Lanzillotta, D., Musella, S., Di [...]

2022-12-21T21:16:07+01:00Dicembre 21st, 2022|Pubblicazioni|

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization

Abstract The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we [...]

2022-11-26T10:56:11+01:00Novembre 26th, 2022|Pubblicazioni|

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES-1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase-1 (mPGES-1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different [...]

2022-11-16T14:18:42+01:00Novembre 16th, 2022|Pubblicazioni|

Identification of 2,4-Dinitro-Biphenyl-Based Compounds as MAPEG Inhibitors

Abstract Multipronged strategy: 2,4-Dinitro-biphenyl-based compounds were identified as inhibitors of leukotriene C4 synthase (LTC4S) and 5-lipoxygenase-activating protein (FLAP), both members of the “Membrane Associated Proteins in [...]

2022-11-16T14:09:58+01:00Novembre 16th, 2022|Pubblicazioni|
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