An adamantylureido-benzylamide aniline as FLAP/sEH dual inhibitor: Rational design, in vitro and in vivo lipidomic profiling
AUTORI:Tania Ciaglia, Danilo D'Avino, Paul M. Jordan, Simone Di Micco, Simona Musella, Hannes Engelbrecht, Lukas Klaus Peltner, Veronica Di Sarno, Fabrizio Merciai, Sara Perna, Gerardina Smaldone, Francesca Di Matteo, Valeria Napolitano, Rosario Stimoli, Giuseppe Bifulco, Giacomo Pepe, Eduardo Maria Sommella, [...]
Computational, crystallographic, and biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4
AUTORI: Simone Di Micco, Maria Carmina Scala, Marina Sala, Giovanni Barra ,Ornella Ghilardi, Pietro Campiglia, Giuseppe Bifulco, Luigi Vitagliano, Alessia Ruggiero - Abstract The members of the annexin family are proteins involved in important biological processes that share a common [...]
The endocannabinoidome–gut microbiome–brain axis as a novel therapeutic target for autism spectrum disorder
AUTORI: Antonella Campanale, Dario Siniscalco & Vincenzo Di Marzo - Abstract Introduction Autism spectrum disorder (ASD) is characterized by disruption of the gut–brain axis, which leads to behavioral, psychiatric, metabolic and gastrointestinal symptoms. Effective ASD treatments are limited. Research highlights [...]
Palmitoylethanolamide: A Multifunctional Molecule for Neuroprotection, Chronic Pain, and Immune Modulation
AUTORI: Valeria Di Stefano, Luca Steardo, Martina D’Angelo, Francesco Monaco and Luca Steardo _______________________________________________ ABSTRACT Palmitoylethanolamide (PEA) is an endogenous lipid mediator belonging to the N-acyl-ethanolamine family, widely recognized for its multifaceted effects on neuroprotection, chronic pain management, and immune [...]
Exploring the COVID-19 pandemic’s influence on eating disorders: insights from an Italian residential center
AUTORI: Francesco Monaco, Annarita Vignapiano,Paolo Meneguzzo, Stefania Palermo, Annaluce Caputo, Ilona Forte, Antonella Boccia, Anna Longobardi, Marilena Di Pierro, Ernesta Panarello, Benedetta Di Gruttola, Annarita Mainardi, Rossella Bonifacio, Emanuela Ferrara, Alessandra Marenna, Martina Piacente, Stefania Landi, Mauro Cozzolino, Luca Steardo [...]
Gut dysbiosis: cause or consequence of intestinal inflammation in celiac disease?
AUTORI: Stefano Leo, Maureen M Leonard, Francesco Valitutti & Alessio Fasano _______________________________________________ Introduction Celiac disease (CeD) is an immune-mediated condition that occurs in genetically predisposed individuals ingesting gluten. It is characterized by enteropathy leading to both gastrointestinal and extra-intestinal symptoms. [...]
Impact of sex and complex PTSD comorbidity on pharmacological treatment response in bipolar disorder patients
AUTORI: Luca Steardo Jr., Michele Fornaro, Martina D'Angelo, Valeria Di Stefano, Francesco Monaco, Caterina Scuderi, Luca Steardo, Marta Valenza. - Background The prevalence of bipolar disorder (BD) is similar in men and women. However, factors such as sex and comorbid [...]
Presence of Psychotic Spectrum Symptoms Before Age 12 in Schizophrenia Patients: A Retrospective Study on Clinical Implications for Early Detection and Intervention
AUTORI: Pietro Carmellini, Alessandro Cuomo, Annarita Vignapiano, Francesco Monaco, Simone Pardossi, Bernardo Firenzuoli, Andrea Fagiolini - Abstract Background/Objectives: Schizophrenia is a severe psychiatric disorder, with onset typically occurring in late adolescence or early adulthood. Early identification of psychotic symptoms, especially [...]
Computational, crystallographic, and biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4
AUTORI: Simone Di Micco, Maria Carmina Scala, Marina Sala, Giovanni Barra, Ornella Ghilardi, Pietro Campiglia, Giuseppe Bifulco, Luigi Vitagliano, Alessia Ruggiero. Abstract The members of the annexin family are proteins involved in important biological processes that share a common propensity, [...]
The Role of microRNA-22 in Metabolism
AUTORI: Simone Tomasini, Paolo Vigo, Francesco Margiotta, Ulrik Soberg Scheele, Riccardo Panella, J and Sakari Kauppinen Abstract microRNA-22 (miR-22) plays a pivotal role in the regulation of metabolic processes and has emerged as a therapeutic target in metabolic disorders, including [...]
Proximity-based solutions for optimizing autism spectrum disorder treatment: integrating clinical and process data for personalized care
AUTORI: Annarita Vignapiano, Luca Steardo Jr, Francesco Monaco, Stefania Landi, Carlo Mancuso, Gianvito Petrillo, Alessandra Marenna, Claudio Pagano, Martina Piacente, Stefano Leo, Benedetta Di Gruttola, Carminia Marina Ingenito, Marco Solmi, Rossella Bonifacio, Maria Pontillo, Giorgio Di Lorenzo, Alessio Fasano, Giulio [...]
Decoding neural circuit dysregulation in bipolar disorder: Toward an advanced paradigm for multidimensional cognitive, emotional, and psychomotor treatment
AUTORI: Luca Steardo Jr., Martina D’Angelo, Francesco Monaco, Valeria Di Stefano, Luca Steardo Abstract Bipolar disorder (BD) is characterized by a complex constellation of emotional, cognitive, and psychomotor disturbances, each deeply intertwined with underlying dysfunctions in large-scale brain networks and [...]
Digital Interventions for the Rehabilitation of First-Episode Psychosis: An Integrated Perspective
AUTORI: Annarita Vignapiano, Francesco Monaco, Ernesta Panarello, Stefania Landi, Benedetta Di Gruttola, Raffaele Malvone, Vassilis Martiadis, Fabiola Raffone, Alessandra Marenna, Maria Pontillo, Valeria Di Stefano, Martina D'Angelo, Luca Steardo Jr, Giulio Corrivetti. Abstract Background: The integration of digital health technologies has transformed mental healthcare, particularly for young adults with First-Episode Psychosis (FEP). [...]
Neuroprotective Potential of Indole-Based Compounds: A Biochemical Study on Antioxidant Properties and Amyloid Disaggregation in Neuroblastoma Cells
Abstract Based on the established neuroprotective properties of indole-based compounds and their significant potential as multi-targeted therapeutic agents, a series of synthetic indole–phenolic compounds was evaluated as multifunctional neuroprotectors. Each compound demonstrated metal-chelating properties, particularly in sequestering copper ions, with [...]
Decoding Schizophrenia: How AI-Enhanced fMRI Unlocks New Pathways for Precision Psychiatry
Abstract Schizophrenia, a highly complex psychiatric disorder, presents significant challenges in diagnosis and treatment due to its multifaceted neurobiological underpinnings. Recent advancements in functional magnetic resonance imaging (fMRI) and artificial intelligence (AI) have revolutionized the understanding and management of this [...]