Anti-Inflammatory Activity of Monoterpene Phenol Dimers from Satureja bachtiarica
AUTORI: Simone Di Micco; Milena Masullo; Noemi Marigliano; Ester Colarusso; Marzieh Rahmani Samani; Anna Schettino; Anella Saviano; Francesco Maione; Sonia Piacente; Giuseppe Bifulco. - Abstract Satureja bachtiarica (Bakhtiari savory) is an aromatic herb cultivated both as a culinary spice and [...]
Identification of a New, Potent, and Stable Tetrahydroquinoline-Based 5-LOX/sEH Dual Inhibitor with Polymodal Anti-Inflammatory Activity in Acute Pancreatitis
AUTORI: Danilo D’Avino; Tania Ciaglia; Paul M. Jordan; Simone Di Micco; Simona Musella; Veronica Di Sarno; Fabrizio Merciai; Sara Perna; Gerardina Smaldone; Francesca Di Matteo; Valeria Napolitano; Rosario Stimoli; Ignazio Sardo; Ornella Ricci; Giuseppe Bifulco; Eduardo Maria Sommella; Manuela Giovanna [...]
A Global Analysis of the Complex Structural Organization of KCTD Proteins and Their Functional Implications
AUTORI: Nicole Balasco; Luciana Esposito; Simone Di Micco; Luigi Vitagliano. - Abstract KCTD proteins exhibit significant structural complexity, arising from their modular organization, oligomerization, and intricate biological partnerships. Although their biological importance has been assessed for two decades, the biochemical [...]
Probiotics and Antibiotics: From Empirical Practice to a Biological Rationale for Targeted Choice During Antibiotic Therapy
AUTORI: Matera, M.; Biagioli, V.; Leo, S.; Drago, L. - Abstract Antibiotic therapy represents one of the strongest ecological perturbations of the human gut microbiota, inducing rapid and often prolonged alterations in community structure, metabolic activity, and functional resilience. While [...]
A Combined Colon Organoid-Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease
AUTORI: Francesco Maraiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini - Abstract Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut [...]
Structural basis of calcium and phosphatidylserine binding annexin V and beyond
AUTORI: Luigi Vitagliano, Alessia Ruggiero, Giuseppe Bifulco, Simone Di Micco - Abstract Annexins are an important family of proteins that play key roles in crucial biological contexts, sharing the common property of binding membrane phospholipids in a Ca2+-dependent manner. For [...]
An adamantylureido-benzylamide aniline as FLAP/sEH dual inhibitor: Rational design, in vitro and in vivo lipidomic profiling
AUTORI:Tania Ciaglia, Danilo D'Avino, Paul M. Jordan, Simone Di Micco, Simona Musella, Hannes Engelbrecht, Lukas Klaus Peltner, Veronica Di Sarno, Fabrizio Merciai, Sara Perna, Gerardina Smaldone, Francesca Di Matteo, Valeria Napolitano, Rosario Stimoli, Giuseppe Bifulco, Giacomo Pepe, Eduardo Maria Sommella, [...]
Computational, crystallographic, and biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4
AUTORI: Simone Di Micco, Maria Carmina Scala, Marina Sala, Giovanni Barra ,Ornella Ghilardi, Pietro Campiglia, Giuseppe Bifulco, Luigi Vitagliano, Alessia Ruggiero - Abstract The members of the annexin family are proteins involved in important biological processes that share a common [...]
The endocannabinoidome–gut microbiome–brain axis as a novel therapeutic target for autism spectrum disorder
AUTORI: Antonella Campanale, Dario Siniscalco & Vincenzo Di Marzo - Abstract Introduction Autism spectrum disorder (ASD) is characterized by disruption of the gut–brain axis, which leads to behavioral, psychiatric, metabolic and gastrointestinal symptoms. Effective ASD treatments are limited. Research highlights [...]
Palmitoylethanolamide: A Multifunctional Molecule for Neuroprotection, Chronic Pain, and Immune Modulation
AUTORI: Valeria Di Stefano, Luca Steardo, Martina D’Angelo, Francesco Monaco and Luca Steardo _______________________________________________ ABSTRACT Palmitoylethanolamide (PEA) is an endogenous lipid mediator belonging to the N-acyl-ethanolamine family, widely recognized for its multifaceted effects on neuroprotection, chronic pain management, and immune [...]
Exploring the COVID-19 pandemic’s influence on eating disorders: insights from an Italian residential center
AUTORI: Francesco Monaco, Annarita Vignapiano,Paolo Meneguzzo, Stefania Palermo, Annaluce Caputo, Ilona Forte, Antonella Boccia, Anna Longobardi, Marilena Di Pierro, Ernesta Panarello, Benedetta Di Gruttola, Annarita Mainardi, Rossella Bonifacio, Emanuela Ferrara, Alessandra Marenna, Martina Piacente, Stefania Landi, Mauro Cozzolino, Luca Steardo [...]
Gut dysbiosis: cause or consequence of intestinal inflammation in celiac disease?
AUTORI: Stefano Leo, Maureen M Leonard, Francesco Valitutti & Alessio Fasano _______________________________________________ Introduction Celiac disease (CeD) is an immune-mediated condition that occurs in genetically predisposed individuals ingesting gluten. It is characterized by enteropathy leading to both gastrointestinal and extra-intestinal symptoms. [...]
Impact of sex and complex PTSD comorbidity on pharmacological treatment response in bipolar disorder patients
AUTORI: Luca Steardo Jr., Michele Fornaro, Martina D'Angelo, Valeria Di Stefano, Francesco Monaco, Caterina Scuderi, Luca Steardo, Marta Valenza. - Background The prevalence of bipolar disorder (BD) is similar in men and women. However, factors such as sex and comorbid [...]
Presence of Psychotic Spectrum Symptoms Before Age 12 in Schizophrenia Patients: A Retrospective Study on Clinical Implications for Early Detection and Intervention
AUTORI: Pietro Carmellini, Alessandro Cuomo, Annarita Vignapiano, Francesco Monaco, Simone Pardossi, Bernardo Firenzuoli, Andrea Fagiolini - Abstract Background/Objectives: Schizophrenia is a severe psychiatric disorder, with onset typically occurring in late adolescence or early adulthood. Early identification of psychotic symptoms, especially [...]
Computational, crystallographic, and biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4
AUTORI: Simone Di Micco, Maria Carmina Scala, Marina Sala, Giovanni Barra, Ornella Ghilardi, Pietro Campiglia, Giuseppe Bifulco, Luigi Vitagliano, Alessia Ruggiero. Abstract The members of the annexin family are proteins involved in important biological processes that share a common propensity, [...]
