The Role of microRNA-22 in Metabolism
AUTORI: Simone Tomasini, Paolo Vigo, Francesco Margiotta, Ulrik Soberg Scheele, Riccardo Panella, J and Sakari Kauppinen Abstract microRNA-22 (miR-22) plays a pivotal role in the regulation of metabolic processes and has emerged as a therapeutic target in metabolic disorders, including [...]
Proximity-based solutions for optimizing autism spectrum disorder treatment: integrating clinical and process data for personalized care
AUTORI: Annarita Vignapiano, Luca Steardo Jr, Francesco Monaco, Stefania Landi, Carlo Mancuso, Gianvito Petrillo, Alessandra Marenna, Claudio Pagano, Martina Piacente, Stefano Leo, Benedetta Di Gruttola, Carminia Marina Ingenito, Marco Solmi, Rossella Bonifacio, Maria Pontillo, Giorgio Di Lorenzo, Alessio Fasano, Giulio [...]
Decoding neural circuit dysregulation in bipolar disorder: Toward an advanced paradigm for multidimensional cognitive, emotional, and psychomotor treatment
AUTORI: Luca Steardo Jr., Martina D’Angelo, Francesco Monaco, Valeria Di Stefano, Luca Steardo Abstract Bipolar disorder (BD) is characterized by a complex constellation of emotional, cognitive, and psychomotor disturbances, each deeply intertwined with underlying dysfunctions in large-scale brain networks and [...]
Digital Interventions for the Rehabilitation of First-Episode Psychosis: An Integrated Perspective
AUTORI: Annarita Vignapiano, Francesco Monaco, Ernesta Panarello, Stefania Landi, Benedetta Di Gruttola, Raffaele Malvone, Vassilis Martiadis, Fabiola Raffone, Alessandra Marenna, Maria Pontillo, Valeria Di Stefano, Martina D'Angelo, Luca Steardo Jr, Giulio Corrivetti. Abstract Background: The integration of digital health technologies has transformed mental healthcare, particularly for young adults with First-Episode Psychosis (FEP). [...]
Neuroprotective Potential of Indole-Based Compounds: A Biochemical Study on Antioxidant Properties and Amyloid Disaggregation in Neuroblastoma Cells
Abstract Based on the established neuroprotective properties of indole-based compounds and their significant potential as multi-targeted therapeutic agents, a series of synthetic indole–phenolic compounds was evaluated as multifunctional neuroprotectors. Each compound demonstrated metal-chelating properties, particularly in sequestering copper ions, with [...]
Decoding Schizophrenia: How AI-Enhanced fMRI Unlocks New Pathways for Precision Psychiatry
Abstract Schizophrenia, a highly complex psychiatric disorder, presents significant challenges in diagnosis and treatment due to its multifaceted neurobiological underpinnings. Recent advancements in functional magnetic resonance imaging (fMRI) and artificial intelligence (AI) have revolutionized the understanding and management of this [...]
Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents
ABSTRACT Objective To identify the COVID-19 impact on well-being/mental health, coping strategies and risk factors in adolescent worldwide. Method Anonymous online multi-national/language survey in the general population (representative/weighted non-representative samples, 14-17years), measuring change in well-being (WHO-5/range=0-100) and psychopathology (validated composite [...]
Identification of Honokiol-Based Scaffold to Design Tankyrase 1/2 Inhibitors by In Silico and In Vitro Studies
Abstract Recently, we identified magnolol bioinspired derivatives as new Tankyrase 1/2 (TNKS1/2) inhibitors by our Inverse Virtual Screening protocol. Based on these findings, in the present contribution, we enlarged our investigation of neolignans to the natural product honokiol (1) and [...]
METABOLIC MANAGEMENT MODEL IN PSYCHIATRIC OUTPATIENTS: A REAL-WORLD EXPERIENCE
Summary Obesity and weight gain represent a challenging issue in people suffering from schizophrenia and other severe mental illnesses (SMI). Most of clinical guidelines for the management of overweight and obesity in people with SMI share a stepwise approach starting [...]
Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study
Abstract International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an online, international, anonymous survey measuring changes in well-being (WHO-5) and a [...]
Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses
Abstract There is no multi-country/multi-language study testing a-priori multivariable associations between non- modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report on sentative/weighted non-probability samples. The Collaborative Outcomes [...]
Enhancing the treatment of eating disorders: insights and challenges from the Regional Residential Center “Mariconda” in Salerno
Summary Objective. Eating Disorders are serious psychological conditions causing significant physical and mental health impairments. They have high mortality and suicide rates, and many affected individuals do not receive adequate treatment. Aim. This study aimed to evaluate the preliminary results [...]
An advanced Artificial Intelligence platform for a personalised treatment of Eating Disorders
Abstract Introduction: Eating Disorders (EDs) affect individuals globally and are associated with significant physical and mental health challenges. However, access to adequate treatment is often hindered by societal stigma, limited awareness, and resource constraints. Methods: The project aims to utilize [...]
Exploring the Efficacy of Lurasidone as an Adjunct to Fluvoxamine in the Treatment of Obsessive-Compulsive Disorder with Comorbid Restrictive Anorexia Nervosa: A Case Report
Abstract Introduction: Eating Disorders (EDs) significantly impact quality of life and social functioning, with varying prevalence rates and a recent rise in diagnosis due to the COVID-19 pandemic. Anorexia Nervosa (AN) frequently co-occurs with Obsessive-Compulsive Disorder (OCD), and this comorbidity [...]
Optimizing and Predicting Antidepressant Efficacy in Patients with Major Depressive Disorder Using Multi-Omics Analysis and the Opade AI Prediction Tools
Abstract According to the World Health Organization (WHO), major depressive disorder (MDD) is the fourth leading cause of disability worldwide and the second most common disease after cardiovascular events. Approximately 280 million people live with MDD, with incidence varying by [...]
